HPLC – Apical Scientific

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Nacalai USA provides Cosmosil brand HPLC columns. The Cosmosil chromatography product line includes several robust reversed phase and prep columns as well as specialty columns such as the Cholester (cholesteryl group), NPE (nitrophenylethyl group), PYE (pyrenylethyl group) and Sugar-D. Cosmosil Buckyprep (pyrenylpropyl group) and PBB (pentabromobenzyl group) columns are well recognized worldwide for Fullerene separation.

Our product are showed as follow:

Core-Shell Columns

1. COSMOCORE 2.6C18

2.6 µm Core Shell Particle
Increased loading capacity
Excellent pH stability (1.5-10)

Analytical Column (Particle size : 2.6 µm) COSMOCORE 2.6C18

Product Name	Size	Product No.
COSMOCORE 2.6C18	2.1 mm I.D. x 30 mm	12632-31
	2.1 mm I.D. x 50 mm	12631-41
	2.1 mm I.D. x 75 mm	12630-51
	2.1 mm I.D. x 100 mm	12614-71
	2.1 mm I.D. x 150 mm	12612-91
	3.0 mm I.D. x 30 mm	12611-01
	3.0 mm I.D. x 50 mm	12609-51
	3.0 mm I.D. x 75 mm	12608-61
	3.0 mm I.D. x 100 mm	12607-71
	3.0 mm I.D. x 150 mm	12602-21
	4.6 mm I.D. x 30 mm	12601-31
	4.6 mm I.D. x 50 mm	12600-41
	4.6 mm I.D. x 75 mm	12599-91
	4.6 mm I.D. x 100 mm	12598-01
	4.6 mm I.D. x 150 mm	12597-11
	4.6 mm I.D. x 250 mm	12596-21

2. COSMOCORE 2.6Cholester

Cholesterol-bonded reversed-phase core-shell column
Usable under the same conditions as C18 columns
Better selectivity for cis-trans isomers, polyphenols, and natural product

Analytical Column (Particle size : 2.6 µm) COSMOCORE 2.6 Cholester Column

Product Name	Size	Product No.
COSMOCORE 2.6Cholester	2.1 mm I.D. x 30 mm	12858-91
	2.1 mm I.D. x 50 mm	12859-81
	2.1 mm I.D. x 75 mm	12860-41
	2.1 mm I.D. x 100 mm	12861-31
	2.1 mm I.D. x 150 mm	12862-21
	3.0 mm I.D. x 30 mm	12863-11
	3.0 mm I.D. x 50 mm	12864-01
	3.0 mm I.D. x 75 mm	12866-81
	3.0 mm I.D. x 100 mm	12867-71
	3.0 mm I.D. x 150 mm	12868-61
	4.6 mm I.D. x 30 mm	12869-51
	4.6 mm I.D. x 50 mm	12870-11
	4.6 mm I.D. x 75 mm	12871-01
	4.6 mm I.D. x 100 mm	12872-91
	4.6 mm I.D. x 150 mm	12873-81
	4.6 mm I.D. x 250 mm	12875-61

3. COSMOCORE 2.6PBr

Separate hydrophilic compounds in reversed-phase conditions
Retain hydrophilic compounds longer than C18
Greater sample loading capacity than HILIC
High performance similar to sub-2 µm particles with lower back pressure

Suitable Samples

Hydrophilic compounds
Nucleic acids and derivatives
Surfactants
Glycosides
Peptides

Analytical Column (Particle size : 2.6 µm) COSMOCORE 2.6PBr Column

Product Name	Size	Product No.
COSMOCORE 2.6PBr	2.1 mm I.D. x 30 mm	13692-21
	2.1 mm I.D. x 50 mm	13693-11
	2.1 mm I.D. x 75 mm	13694-01
	2.1 mm I.D. x 100 mm	13695-91
	2.1 mm I.D. x 150 mm	13697-71
	3.0 mm I.D. x 30 mm	13698-61
	3.0 mm I.D. x 50 mm	13699-51
	3.0 mm I.D. x 75 mm	13700-01
	3.0 mm I.D. x 100 mm	13701-91
	3.0 mm I.D. x 150 mm	13703-71
	4.6 mm I.D. x 30 mm	13705-51
	4.6 mm I.D. x 50 mm	13712-51
	4.6 mm I.D. x 75 mm	13714-31
	4.6 mm I.D. x 100 mm	13715-21
	4.6 mm I.D. x 150 mm	13719-81
	4.6 mm I.D. x 250 mm	13734-71

Other sizes may be available.

UHPLC-compatible prefilter

Product Name	Product No.	In	Out	Description	PKG Size
U-Fil UHPLC-compatible prefilter	12571-31	UHPLC	UHPLC	Filter: 0.5 µm Tubing connecting diameter: 1/16	1 PKG
U-Fil UHPLC-compatible prefilter	12572-21	HPLC	UHPLC	Filter: 0.5 µm Tubing connecting diameter: 1/16	1 PKG
U-Fil replacement filter	28150	-	-	Filter: 0.5 µm, Material: SUS316L	5 PKG/ Pack

HPLC Column

1. COSMOSIL 5C₁₈-MS-II

Multi-purpose C18 Column
High reproducibility
A wide range of applications

Product Name	Size	Product No.
COSMOSIL 5C₁₈-MS-II Guard Column/Guard Cartridge
	4.6 mm I.D. x 10 mm	38014-31
	4.6 mm I.D. x 10 mm Cartridge	38015-89
	10 mm I.D. x 20 mm	38016-11
	20 mm I.D. x 20 mm	05790-81
	20 mm I.D. x 50 mm	34371-71
	28 mm I.D. x 50 mm	34347-01
COSMOSIL 5C₁₈-MS-II Packed Column
	1.0 mm I.D. x 50 mm	02824-31
	1.0 mm I.D. x 150 mm	02896-01
	2.0 mm I.D. x 30 mm	05876-71
	2.0 mm I.D. x 50 mm	04355-21
	2.0 mm I.D. x 100 mm	05597-31
	2.0 mm I.D. x 150 mm	38025-91
	2.0 mm I.D. x 250 mm	05761-61
	3.0mmI.D. x 100mm	05458-51
	3.0 mm I.D. x 150 mm	34245-31
	3.0 mm I.D. x 250 mm	34254-11
	4.6 mm I.D. x 30 mm	34341-61
	4.6 mm I.D. x 50 mm	38017-01
	4.6 mm I.D. x 100 mm	38018-91
	4.6 mm I.D. x 150 mm	38019-81
	4.6 mm I.D. x 250 mm	38020-41
	6.0 mm I.D. x 150 mm	38021-31
	6.0 mm I.D. x 250 mm	38022-21
	10 mm I.D. x 50 mm	05789-21
	10 mm I.D. x 150 mm	34355-91
	10 mm I.D. x 250 mm	38023-11
	20 mm I.D. x 150 mm	05091-41
	20 mm I.D. x 250 mm	38024-01
	28 mm I.D. x 250 mm	05760-71

2. COSMOSIL 3C₁₈-EB

Excellent for Basic compounds
Suitable for Drug Analysis

Product Name	Size	Product No.
COSMOSIL 3C₁₈-EB Guard Column	4.6 mm I.D. x 10 mm	09839-41
COSMOSIL 3C₁₈-EB Guard Cartridge (2 PKG)**	2.0 mm I.D. x 10 mm	11892-74
COSMOSIL 3C₁₈-EB Guard Cartridge (2 PKG)**	4.6 mm I.D. x 10 mm	11890-94
COSMOSIL 3C₁₈-EB Packed Column	2.0 mm I.D. x 50 mm	09794-21
	2.0 mm I.D. x 75 mm	09795-11
	2.0 mm I.D. x 100 mm	09796-01
	2.0 mm I.D. x 150 mm	09797-91
	2.0 mm I.D. x 250 mm	09798-81
	3.0 mm I.D. x 50 mm	09799-71
	3.0 mm I.D. x 75 mm	09800-21
	3.0 mm I.D. x 100 mm	09811-81
	3.0 mm I.D. x 150 mm	09814-51
	3.0 mm I.D. x 250 mm	09827-91
	4.6 mm I.D. x 50 mm	09840-01
	4.6 mm I.D. x 75 mm*	09841-91
	4.6 mm I.D. x 100 mm*	09842-81
	4.6 mm I.D. x 150 mm*	09843-71
	4.6 mm I.D. x 250 mm	09844-61

3. COSMOSIL 5C₁₈-AR-II

Features strong acid resistance
Suitable for acid compounds and peptides

Analytical Column (Particle Size : 5 µm) COSMOSIL 5C₁₈-AR-II

Product Name	Size	Product No.
COSMOSIL 5C₁₈-AR-II Guard Column/Guard Cartridge
	4.6 mm I.D. x 10 mm	38141-61
	4.6 mm I.D. x 10 mm Cartridge	38008-89
	10 mm I.D. x 20 mm	38148-91
	20 mm I.D. x 20 mm	34458-51
	20 mm I.D. x 50 mm	34479-81
	28 mm I.D. x 50 mm	34363-81
COSMOSIL 5C₁₈-AR-II Packed Column
	1.0 mm I.D. x 50 mm	02955-21
	1.0 mm I.D. x 150 mm	02951-61
	2.0 mm I.D. x 30 mm	05098-71
	2.0 m m I.D. x 50 mm	34400-81
	2.0 mm I.D. x 100 mm	34469-11
	2.0 mm I.D. x 150 mm	37992-51
	2.0 mm I.D. x 250 mm	05272-71
	3.0 mm I.D. x 100 mm	05791-71
	3.0 mm I.D. x 150 mm	38028-61
	3.0 mm I.D. x 250 mm	38029-51
	4.6 mm I.D. x 30 mm	05877-61
	4.6 mm I.D. x 50 mm	38142-51
	4.6 mm I.D. x 100 mm	38143-41
	4.6 mm I.D. x 150 mm	38144-31
	4.6 mm I.D. x 250 mm	38145-21
	6.0 mm I.D. x 150 mm	38146-11
	6.0 mm I.D. x 250 mm	38147-01
	10 mm I.D. x 50 mm	05369-21
	10 mm I.D. x 150 mm	34350-41
	10 mm I.D. x 250 mm	38149-81
	20 mm I.D. x 150 mm	34316-01
	20 mm I.D. x 250 mm	38150-41
	28 mm I.D. x 250 mm	34362-91

4.6 mm I.D. x 10 mm Cartrige contains 3 PKG. Cartridge Holder (Product number: 38009-79) is required.

Preparative Column (Particle Size : 15 µm) COSMOSIL 15C₁₈-AR-II

Product Name	Size	Product No.
COSMOSIL 15C₁₈-AR-II Guard Column
	28 mml.D. x 50 mm	38030-11
	50 mml.D. x 50 mm	38057-81
COSMOSIL 15C₁₈-AR-II Packed Column
	28 mml.D. x 250 mm	37978-51
	50 mml.D. x 250 mm	38058-71
	50 mml.D. x 500 mm	05884-61

Fast LC Column (Particle Size : 3µm) COSMOSIL 3C₁₈-AR-II

Product Name	Size	Product No.
COSMOSIL 3C₁₈-AR-II Packed Column
	2.0 mm l.D. x 50 mm	05478-91
	4.6 mm l.D. x 10 mm	38068-41
	4.6 mm l.D. x 50 mm	38069-31
	4.6 mm l.D. x 100 mm	38070-91

4. COSMOSIL 5C₁₈-PAQ

Compatible with 100% water based mobile phase
Suitable for hydrophilic compounds

Analytical Column (Particle Size : 5 µm) COSMOSIL 5C₁₈-PAQ

Product Name	Size	Product No.
COSMOSIL 5C₁₈-PAQ Guard Column
	4.6 mm I.D. x 10 mm	02484-91
	10 mm I.D. x 20 mm	34457-61
	20 mm I.D. x 20 mm	05803-11
	20 mm I.D. x 50 mm	05804-01
	28 mm I.D. x 50 mm	34455-81
COSMOSIL 5C₁₈-PAQ Packed Column
	1.0 mm I.D. x 50 mm	05792-61
	1.0 mm I.D. x 150 mm	05793-51
	2.0 mm I.D. x 30 mm	05878-51
	2.0 mm I.D. x 50 mm	05794-41
	2.0 mm I.D. x 100 mm	05470-71
	2.0 mm I.D. x 150 mm	34449-71
	2.0 mm I.D. x 250 mm	05795-31
	3.0 mm I.D. x 100 mm	05796-21
	3.0 mm I.D. x 150 mm	05797-11
	3.0 mm I.D. x 250 mm	05798-01
	4.6 mm I.D. x 30 mm	05879-41
	4.6 mm I.D. x 50 mm	34451-21
	4.6 mm I.D. x 100 mm	05799-91
	4.6 mm I.D. x 150 mm	02486-71
	4.6 mm I.D. x 250 mm	02485-81
	6.0 mm I.D. x 150 mm	34419-61
	6.0 mm I.D. x 250 mm	05800-41
	10 mm I.D. x 50 mm	05801-31
	10 mm I.D. x 150 mm	34466-41
	10 mm I.D. x 250 mm	34376-21
	20 mm I.D. x 150 mm	34476-11
	20 mm I.D. x 250 mm	34373-51
	28 mm I.D. x 250 mm	34456-71

Preparative Column (Particle Size : 15 µm) COSMOSIL 15C₁₈-PAQ

Product Name	Size	Product No.
COSMOSIL 15C₁₈-PAQ Guard Column
	28 mm l.D. x 50 mm	05887-31
	50 mm l.D. x 50 mm	05889-11
COSMOSIL 15C₁₈-PAQ Packed Column
	28 mm l.D. x 250 mm	05888-21
	50 mm l.D. x 250 mm	05890-71
	50 mm l.D. x 500 mm	05891-61

Protein Separation Columns (Wide Pore Columns)

1. COSMOGEL IEX Series

Available in 3 different ion-exchange modes
(Anion-exchange type, Cation-exchange type, Amphoteric ion-exchange type)
Available for 3 different application areas
(for Purification, for Ultra-fast analysis, for Precise analysis)
For separation of biopolymers such as proteins or nucleic acids?

Ion Exchange Mode	Product Name	Application	Size I.D. x Length (mm)	Product Number
Anion-exchange Type	COSMOGEL IEX Type Q	For Purification	4.6 x 50	06266-31
	COSMOGEL IEX Type Q-N	For Ultra-fast Analysis	4.6 x 30	06264-51
	COSMOGEL IEX Type Q-N	For Precise Analysis	4.6 x 100	06258-41
Cation-exchange Type	COSMOGEL IEX Type S	For Purification	4.6 × 50	06252-01
	COSMOGEL IEX Type S-N	For Ultra-fast Analysis	4.6 x 30	06251-11
	COSMOGEL IEX Type S-N	For Precise Analysis	4.6 × 100	06250-21
Amphoteric ion-exchange type	COSMOGEL IEX Type M	For Purification	4.6 x 50	06248-71
Amphoteric ion-exchange type	COSMOGEL IEX Type M-N	For Precise Analysis	4.6 x 100	06244-11

2. COSMOSIL Protein-R

Excellent separation
High recovery rate
Outstanding stability at low pH

Product Name	Size	Product No.
COSMOSIL Protein-R Guard Column
	4.6 mm l.D. x 10 mm	06518-31
	10 mm l.D. x 20 mm	06528-01
COSMOSIL Protein-R Packed Column
	2.0 mm l.D. x 150 mm	06514-71
	4.6 mm l.D. x 50 mm	06525-31
	4.6 mm l.D. x 150 mm	06526-21
	4.6 mm l.D. x 250 mm	06527-11
	10 mm l.D. x 150 mm	06529-91
	10 mm l.D. x 250 mm	06530-51
	20 mm l.D. x 150 mm	06531-41
	20 mm l.D. x 250 mm	06532-31

3. COSMOSIL Diol-120-II, Diol-300-II, Diol-1000-II

Separate large hydrophilic molecules, such as proteins, polysaccharides and nucleic acids, by molecular size
Reduce undesirable adsorption
High pressure tolerance with silica gel-based packing material
Different products cover a wide range of molecular weight

COSMOSIL 5Diol-120-II

Product Name	Size	Product No.
COSMOSIL 5Diol-120-II Guard Column
COSMOSIL 5Diol-120-II Guard Column	7.5 mm l.D. x 50 mm	38049-91
COSMOSIL 5Diol-120-II Packed Column
	7.5 mm l.D. x 300 mm	38050-51
	7.5 mm l.D. x 600 mm	38051-41

COSMOSIL 5Diol-300-II

Product Name	Size	Product No.
COSMOSIL 5Diol-300-II Guard Column
COSMOSIL 5Diol-300-II Guard Column	7.5 mm l.D. x 50 mm	38052-31
COSMOSIL 5Diol-300-II Packed Column
	7.5 mm l.D. x 300 mm	38053-21
	7.5 mm l.D. x 600 mm	38054-11

COSMOSIL 5Diol-1000-II

Product Name	Size	Product No.
COSMOSIL 5Diol-1000-II Guard Column
COSMOSIL 5Diol-1000-II Guard Column	7.5 mm l.D. x 50 mm	13337-81
COSMOSIL 5Diol-1000-II Packed Column
COSMOSIL 5Diol-1000-II Packed Column	7.5 mm l.D. x 300 mm	13338-71